Louisville vs. Indiana Picks, CFB Predictions & Odds for Saturday, 9/16
The Indiana Hoosiers were able to bounce back from their season-opening loss to the Ohio State Buckeyes with a convincing win over Indiana State this past weekend, and now get to take on an ACC opponent - the Louisville Cardinals. It’s set to be a tough matchup, but we’re here with our favorite approach in the betting markets.
Along with our experts’ best Louisville vs. Indiana picks, we’ll be detailing a BetMGM Sportsbook sign-up bonus worth up to $1,500.
LOUISVILLE VS. INDIANA PICK: Over 52.5 points (-110 at BetMGM Sportsbook)
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CFB Week 2 Picks for Louisville Cardinals vs. Indiana Hoosiers
At first glance, it looks as though the Hoosiers get to have their third straight home game. However, this will be a game played at Lucas Oil Stadium. Of course, that certainly still favors Indiana, as that is where the Indianapolis Colts of the NFL play.
Despite that, the Hoosiers still find themselves as relatively significant underdogs on Saturday. The point spread has been hovering around 10 points, which is quite a difficult number to navigate around depending on which side of it is available. Therefore, the best bet from our Louisville vs. Indiana picks is going to focus on the total, or over/under, so let’s explain why.
CFB Best Bets & Louisville vs. Indiana Predictions for Saturday Including Over 52.5
With our Louisville vs. Indiana picks, we’re going to be targeting a high-scoring contest in this ACC vs. Big Ten matchup. The Cardinals may deserve to be favored, but a double-digit favorite seems quite extreme.
Admittedly, they do have a strong offense led by a senior QB in Jack Plummer, which is proven by their 95 points scored across the first two weeks of the season. Prior to their 56 points just this past weekend, the Cardinals put up 39 points on the road against a conference opponent - Georgia Tech.
Similarly, the Hoosiers offense was firing on all cylinders last weekend with their 41 points. Of course, the argument will then be made that Indiana put up just three points in their season opener. Keep in mind that was against a College Football Playoff-favorite Ohio State Buckeyes team that quite literally set program records on defense.
That’s not what they’ll be facing in a Louisville team that allowed 34 points to a very mediocre Georgia Tech offense. Taking all that into consideration, the best bet from our Louisville vs. Indiana picks is on the over 52.5 points (-110 at BetMGM Sportsbook).
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Latest Louisville vs. Indiana Betting Lines, Odds & Spread for 9/16 via BetMGM
If you’d like to target the best bet from our Louisville vs. Indiana picks with your initial bet, we have the latest odds at BetMGM Sportsbook for their matchup on Saturday below. Based on those prices, an $11 wager on over 52.5 points profits $10 as long as there is at least 52 points scored.
Point spread:
- Louisville Cardinals -9.5 (-110) vs. Indiana Hoosiers +9.5 (-110)
Money line:
- Louisville Cardinals (-390) vs. Indiana Hoosiers (+300)
Total (over/under)
- Over 52.5 (-110) vs. Under 52.5 (-110)
IU Football Score Last Week
We mentioned the Hoosiers win over in-state rival Sycamores last weekend, and here’s that final score:
- Indiana State Sycamores 7 vs. Indiana Hoosiers 41
That offensive performance certainly supports the best bet from our Louisville vs. Indiana picks, so make sure you join BetMGM today to take full advantage while also claiming your $1,500 promo.
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