NFL Preseason Week 1 Picks Straight Up, Odds for All 16 Games + Best Bets
Week 1 of the NFL regular season is officially less than a month away, and we don’t even need to wait nearly that long for a full week of games. That’s because Week 1 of the preseason kicks off Thursday, August 10, and we’re here to help you make the most of it. It’s been six months since we’ve been able to have a whole slate of games to wager on, so there’s plenty to be excited about.
Therefore, our experts have provided their NFL predictions and NFL preseason Week 1 picks for every game below and how you can use them to snag a guaranteed $150 DraftKings Sportsbook sign-up bonus.
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NFL Preseason Week 1 Picks Straight Up for All 16 Games at DraftKings Sportsbook
There’s no denying that the NFL preseason can be one of the most difficult things to handicap and wager on. That’s because teams are not focused on featuring their star players, but rather developing their depth to form the roster they're going to enter the season with. However, our experts are still locked into how each team is expected to approach their games this week, so here are our NFL preseason Week 1 picks for every game straight up:
Thursday, August 10:
- Houston Texans vs. New England Patriots
- Minnesota Vikings vs. Seattle Seahawks
Friday, August 11:
- New York Giants vs. Detroit Lions
- Green Bay Packers vs. Cincinnati Bengals
- Pittsburgh Steelers vs. Tampa Bay Buccaneers
- Atlanta Falcons vs. Miami Dolphins
- Washington Commanders vs. Cleveland Browns
- Denver Broncos vs. Arizona Cardinals
Saturday, August 12:
- Indianapolis Colts vs. Buffalo Bills
- Tennessee Titans vs. Chicago Bears
- New York Jets vs. Carolina Panthers
- Jacksonville Jaguars vs. Dallas Cowboys
- Philadelphia Eagles vs. Baltimore Ravens
- Los Angeles Chargers vs. Los Angeles Rams
Sunday, August 13:
- Kansas City Chiefs vs. New Orleans Saints
- San Francisco 49ers vs. Las Vegas Raiders
NFL Preseason Week 1 Early Spread Picks & Predictions
Of course, making NFL preseason Week 1 picks straight up isn’t always the best way to go given that some teams have rather expensive prices on the money line. Therefore, we have some of our top spread picks for you as well.
The first of which features the matchup between the New York Giants and Detroit Lions. Both teams had similar seasons last year, as the Giants finished 9-7-1 and the Lions finished 9-8. They also both have similar caliber QBs, but of course, we won’t be seeing them in action. Another similarity between them is that New York head coach Brian Daboll is the reigning Coach of the Year and Detroit head coach Dan Campbell is the favorite to win it this season.
Despite all those similarities, it’s difficult to imagine a Campbell-led team taking any game lightly. Not only that, but the Lions recently acquired QB Teddy Bridgewater to back up Jared Goff this season. That means they have an established veteran leading the way, and alongside him will be a rookie RB making a name for himself in Jahmyr Gibbs. So, we’d make the Lions +3 (-110 at DraftKings Sportsbook) a part of our NFL preseason Week 1 picks.
If you’re looking for a different matchup to target, our experts are also eyeing the final game of the week, which features the San Francisco 49ers and Las Vegas Raiders. The former is coming off an NFC Championship Game appearance, while the latter is trying to rebuild after losing long-time starting QB Derek Carr.
Instead, it will by Jimmy Garoppolo leading the Raiders this season, but with his injury history, it's almost certain he won't be active this preseason. That means Brian Hoyer will be featured for Las Vegas, which generally means plenty of turnovers. That’s the 49ers’ specialty, as their defense is unparalleled.
San Francisco is also more likely to have competent QB play, as they’re currently dealing with a true battle between Brock Purdy, Trey Lance and Sam Darnold. Preseason matchups generally favor teams with more motivation to figure things out at key positions, so we’re making the 49ers -4 (-110 at DraftKings Sportsbook) a part of our NFL preseason Week 1 picks as well.
How to Bet on Our Free Picks at DraftKings Sportsbook
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NFL Preseason Week 1 Odds for All 16 Games Provided by DraftKings Sportsbook
We outlined our NFL preseason Week 1 picks straight up, but as for the spreads, here are the latest odds at DraftKings Sportsbook for all 16 games this week:
Thursday, August 10:
- Houston Texans -1.5 (-110) vs. New England Patriots +1.5 (-110)
- Minnesota Vikings +4.5 (-110) vs. Seattle Seahawks -4.5 (-110)
Friday, August 11:
- New York Giants -3 (-110) vs. Detroit Lions +3 (-110)
- Green Bay Packers -4.5 (-110) vs. Cincinnati Bengals +4.5 (-110)
- Pittsburgh Steelers +1 (-110) vs. Tampa Bay Buccaneers -1 (-110)
- Atlanta Falcons -2.5 (-110) vs. Miami Dolphins +2.5 (-110)
- Washington Commanders +3 (-110) vs. Cleveland Browns -3 (-110)
- Denver Broncos -5.5 (-110) vs. Arizona Cardinals +5.5 (-110)
Saturday, August 12:
- Indianapolis Colts -5.5 (-110) vs. Buffalo Bills +5.5 (-110)
- Tennessee Titans +3.5 (-110) vs. Chicago Bears -3.5 (-110)
- New York Jets +3.5 (-110) vs. Carolina Panthers -3.5 (-110)
- Jacksonville Jaguars -4 (-110) vs. Dallas Cowboys +4 (-110)
- Philadelphia Eagles +6 (-110) vs. Baltimore Ravens -6 (-110)
- Los Angeles Chargers +3 (-110) vs. Los Angeles Rams -3 (-110)
Sunday, August 13:
- Kansas City Chiefs +3 (-110) vs. New Orleans Saints -3 (-110)
- San Francisco 49ers -3 (-110) vs. Las Vegas Raiders +3 (-110)
Whether you stick with our best NFL preseason Week 1 picks or another matchup caught your eye, be sure to create a new account at DraftKings today to grab your ‘Bet $5, get $150’ sign-up bonus.
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