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49ers vs. Cardinals Prediction, Player Prop Bets & Odds for 12/17

The biggest spread of the NFL Week 15 slate takes place in Phoenix between the San Francisco 49ers and Arizona Cardinals. The 49ers are 14-point favorites on Sunday, and that’s not too big of a surprise since the 49ers have been dominating teams recently.

Our expert made his 49ers vs. Cardinals prediction and 49ers vs Cardinals player prop bets at FanDuel Sportsbook, where new users can wager $5 on a team’s pre-game money line and win $150 in bonus bets if their team wins. Click here to join FanDuel in time for Sunday's NFC West tilt.

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SAN FRANCISCO 49ERS VS. ARIZONA CARDINALS PREDICTION: 49ers -14 (-110) at FanDuel Sportsbook

If you’re ready to place a wager with our 49ers vs. Cardinals prediction, tap this link to get the ball rolling today with FanDuel before Sunday’s opening kickoff.

San Francisco 49ers vs Arizona Cardinals Prediction for Sunday's Game

The 49ers have cemented themselves as one of the best teams in football this season. With big wins over the Cowboys and Eagles, the 49ers haven’t been just beating teams - they’ve been dominating them. San Francisco's last five wins have come by 31, 13, 18, 23, and 12 points. The last time the 49ers won by less than 10 points was in Week 2, when the 49ers beat the Rams 30-23.

It’s been a roller coaster of a season for the Cardinals. Joshua Dobbs was the quarterback for the Cardinals to start the season, and Dobbs surprised everyone with an outstanding start to the season. In fact, he was so good that the Cardinals traded Dobbs to the Vikings after Kirk Cousins got hurt. But now, Kyler Murray is back after tearing his ACL last season, and he’s led the Cardinals to two wins in their last four games. Even with the Cardinals playing better recently, our expert couldn't pass up the opportunity to back San Francisco in his 49ers vs. Cardinals prediction.

Best Bets for 49ers vs. Cardinals Featuring 49ers -14

Brock Purdy and the 49ers are the team to beat in the NFL. And after beating the Eagles in Philadelphia a few weeks ago, the 49ers have become the clear favorite to win the Super Bowl. The key to San Francisco's success has been the balance between a dangerous offense and a lockdown defense. On offense, Christian McCaffrey is the best running back in football. Plus, Purdy has Deebo Samuel, Brandon Aiyuk, and George Kittle to throw to when he wants. On defense, Nick Bosa and Chase Young are terrorizing the opposing team’s offensive line. That balance should allow the 49ers to win by several touchdowns on Sunday.

It’s no secret that Kyler Murray likes to run. Murray will use his legs at any time which can make him dangerous, but he has a poor matchup against an elite San Francisco defense. Bosa and Young will put pressure on Murray and collapse the pocket, and that will flush him out and into the 49ers’ arms. If the 49ers can limit Murray’s rushing attempts, this game should be over quickly. Our expert’s 49ers vs. Cardinals prediction is on the 49ers -14 (-110), which you can bet at FanDuel Sportsbook.

Bet $5 on Any Money Line & Get $150 in Bonuses if Your Team Wins for 49ers vs. Cardinals

Are you looking to bet $5 on San Francisco’s ML of -1050 and win $150? Instead of winning 47 cents, you would win $150 in bonus bets at FanDuel Sportsbook if you sign up using this link, or any link in this article. The offer is simple - bet $5 on a team’s pre-game money line, and if your team wins, you win $150 in bonus bets.

That means you can wager on the 49ers ML of -1050, which is incredibly steep, and win $150 in bonus bets if the 49ers beat the Cardinals, which is our expert’s 49ers vs. Cardinals prediction. This can’t-miss offer won’t last forever, so create a new account at FanDuel today.

Betting Odds for 49ers vs. Cardinals at FanDuel Sportsbook

As mentioned before, the 49ers are massive favorites in Sunday’s game. Here is the rest of the 49ers vs Cardinals odds, courtesy of FanDuel Sportsbook:

  • Money line: San Francisco 49ers (-1050) vs. Arizona Cardinals (+675)
  • Point spread: San Francisco 49ers -14 (-110) vs. Arizona Cardinals +14 (-110)
  • Game total: Over 48 (-110) vs. Under 48 (-110)

You can tail our 49ers vs. Cardinals prediction at FanDuel Sportsbook to get the best odds and the most generous new-user offer. Activate the link here to join FanDuel.

Injury Report for 49ers vs. Cardinals

Both the 49ers and Cardinals have quite the long injury report heading into the weekend, so here’s the full list:

San Francisco 49ers

  • Arik Armstead (DL) - Questionable
  • Dre Greenlaw (LB) - Questionable
  • Javon Hargrave (DL) - Questionable
  • Charvarius Ward (CB) - Questionable
  • Trent Williams (OL) - Probable
  • Elijah Mitchell (RB) - Probable

Arizona Cardinals

  • Marquise Brown (WR) - Questionable
  • Geoff Swaim (TE) - Questionable
  • Emari Demercado (RB) - Questionable
  • Antonio Hamilton (CB) - Questionable
  • Kevin Strong (DL) - Questionable
  • Kyler Murray (QB - Probable

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