49ers vs. Rams Prediction, Best Bets, Lineups & Odds for Sunday, 9/17
The San Francisco 49ers proved why they entered the season behind only the Philadelphia Eagles to win the entire NFC when they had one of the most convincing victories of Week 1 - a 30-7 win over the Pittsburgh Steelers at home. Now, they get to head back to California for a divisional matchup against the Los Angeles Rams.
With an NFC West rivalry on the horizon, we’ve provided our best 49ers vs. Rams prediction and how you can claim a two-part FanDuel Sportsbook sign-up bonus with a guaranteed $300 value using any 49ers vs. Rams odds.
SAN FRANSISCO 49ERS VS. LOS ANGELES RAMS PREDICTION: 49ers -8 (-110 at FanDuel Sportsbook)
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San Francisco 49ers vs. Los Angeles Rams Prediction for NFL Week 2 on Sunday, 9/17
While the 49ers had one of the most dominant wins to open the season, it’s certainly worth noting that the Rams also took care of business by defeating a different NFC West opponent - the Seattle Seahawks.
However, the 49ers are a whole different beast. While Seattle has had one of the NFL’s worst defenses the past few seasons, the 49ers have had arguably the best. They were able to lock up edge rusher Nick Bosa just prior to the start of the year, and his presence was certainly felt, as San Francisco allowed just seven points to the Steelers.
Before locking in any 49ers vs. Rams picks, it’s also important to check any trends. There is one key trend that’s going to lead into our best 49ers vs. Rams prediction, so let’s get into it.
49ers vs. Rams NFL Picks Including San Francisco -8
It’s clear that the 49ers have been the more dominant team the past two seasons, but many would argue that the Rams are just two seasons removed from winning the Super Bowl over the Cincinnati Bengals. However, San Francisco has been LA’s kryptonite dating back much further than these past two seasons.
In fact, the 49ers are an incredible 8-2 against the Rams in their last 10 games. That means they have also been defeating LA long before they acquired RB Christian McCaffrey. He proved why he’s considered one of, if not the, most versatile backs in Week 1, as he went for 152 rushing yards and a touchdown on top of three receptions.
For those who doubted the 49ers repeating last year’s Cinderella Story behind QB Brock Purdy, they were quickly silenced as well. His numbers may not jump off the page, but his 220 yards and two touchdowns were efficiently performed, and he looked every bit the game manager that San Francisco needs him to be.
It’s also worth noting that the Rams will still be without star WR Cooper Kupp. Finally, when these teams last met, it was also a road game for the 49ers, and they won 31-14. All signs point to them yet again this week, making our best 49ers vs. Rams prediction on San Francisco -8 (-110 at FanDuel Sportsbook).
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49ers vs. Rams Odds & Betting Lines via FanDuel Sportsbook for NFL Week 2 on Sunday, September 17th, 2023
With our best 49ers vs. Rams prediction on San Francisco -8, that has -110 odds at FanDuel Sportsbook, so an $11 wager profits $10 as long as they win by at least nine points. We’ve also listed the point spread, money line and total (over/under) 49ers vs. Rams odds below:
Point spread:
- San Francisco 49ers -8 (-110) vs. Los Angeles Rams +8 (-110)
Money line:
- San Francisco 49ers (-350) vs. Los Angeles Rams (+280)
Total (over/under):
- Over 44 (-110) vs. Under 44 (-110)
49ers vs. Steelers Score Last Week
We mentioned last week’s dominant win when going through our best 49ers vs. Rams picks, and we have it outlined for you here:
- San Francisco 49ers 30 vs. Pittsburgh Steelers 7
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