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Broncos vs. 49ers NFL Best Bets & FanDuel Sportsbook Promotion

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The Denver Broncos head to the Bay Area for a clash against the San Francisco 49ers this Saturday. With Sean Payton, a former Super Bowl victor, at the helm in his debut year for Denver, anticipation is high. The 49ers, under the leadership of Kyle Shanahan in his sixth year, aim to bounce back from last season's NFC Championship defeat to the Eagles, eyeing a Super Bowl triumph. The game commences at 8:30 PM EST at Levi's Stadium in Santa Clara, California.

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Broncos vs. 49ers Best Bets: 49ers +4 (-110 at FanDuel Sportsbook)

As Broncos head coach, Payton, true to his hands-on approach, didn't hesitate to field his main players in the preseason opener against the Cardinals. The aim was clear: understand the team's strengths and weaknesses in real-time play. With Wilson impressively finding the endzone in the opener, he's poised for more playtime on Saturday, possibly commanding the first half. Alongside him, Williams will be making his running back debut. As for the offensive line, as long as Wilson is playing, they'll be guarding.

The focus for the 49ers as the preseason progresses will be Brock Purdy's health and involvement. While he's been spearheading the first-team practice snaps, the team's priority is ensuring his readiness for the inaugural week. Notable players like All-Pro RB Christian McCaffrey, WR Deebo Samuels and TE George Kittle are expected to have minimal preseason involvement. Still, the Lance-Darnold showdown promises excitement and offensive fireworks in the upcoming preseason matches.

The Broncos have already set the precedent of fielding their primary lineup considerably during the preseason, as evidenced by Wilson and his crew's appearance in the initial game. Coach Payton plans to give several of his first-string players another run during the second game against the 49ers, but it's unlikely that Wilson or other leading players will see action past halftime.

On the other hand, the 49ers haven't signaled any strong intent of fielding Purdy during the preseason. If he does participate this Saturday, it might just be a brief stint, perhaps a couple of series at most. However, San Francisco's offense shouldn't be underestimated. With Lance and Darnold, both seasoned players, vying for the backup position behind Purdy, there's plenty to play for. Despite Lance's underwhelming performance in the opener, he'll likely up the ante this game, especially considering the looming threat of Darnold claiming the second-string quarterback spot.

Given the lackluster showing of Denver's reserve defense against the Cardinals, Lance might find success moving the ball. Darnold too is expected to capitalize when he takes the field, particularly against the Broncos' secondary and tertiary defensive units. At this juncture, for both teams, the focus is more on resolving position contests and enhancing roster depth rather than clinching wins. That said, we would tip the scales in favor of the 49ers due to their deeper squad and sheer talent. We’re backing the Niners +4 at FanDuel Sportsbook (-110) in our Broncos vs. 49ers NFL best bets.

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