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Rams vs. 49ers Prediction, Player Prop Bets & Odds for Sunday, 1/7

Two of the hottest teams in the NFL match up in the final weekend of the 2023-24 NFL regular season. The Los Angeles Rams have won six of seven to secure a playoff spot and travel to San Francisco on Sunday. The 49ers have won seven of eight and have secured home-field advantage throughout the NFC playoffs ahead of the season finale against their NFC West rivals.

In the article below, our experts make their Rams vs. 49ers prediction using DraftKings Sportsbook’s Rams vs. 49ers odds while also mentioning some Rams vs. 49ers player prop bets you should consider.

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LOS ANGELES RAMS VS. SAN FRANCISCO 49ERS: 49ERS -4 (-105 at DraftKings Sportsbook)

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Los Angeles Rams vs. San Francisco 49ers Prediction for Sunday’s Game

This is a potentially tricky one as the 49ers are already expected to sit quarterback Brock Purdy for this game, and several other San Francisco starters could sit or see limited roles as well. However, Sam Darnold is a veteran backup who wants to post some numbers to close the season. Plus, the 49ers were embarrassed the last time they played in front of their own fans in a 33-19 loss to Baltimore a couple of weeks ago. They want to go into the playoffs on a positive note.

And, the bigger piece here is the Rams’ decision to rest starters Matthew Stafford, Aaron Donald, Cooper Kupp and others on Sunday.

Our experts like DraftKings’ current Rams vs. 49ers odds of San Francisco -4 (-112 at DraftKings) on Sunday.

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Player Prop Bets & Picks for Rams vs. 49ers Featuring Brandon Aiyuk and Christian McCaffrey

The first of our experts’ two Rams vs. 49ers player prop bets features San Francisco wide receiver Brandon Aiyuk. Teammates Deebo Samuel and George Kittle get more headlines, but Aiyuk actually leads the team in both receptions and yards. He currently has 72 catches for 1,317 yards and seven touchdowns. The current Rams vs. 49ers odds don't yet have him listed, but once available, it he should be set at around 65 receiving yards at DraftKings. Our experts believe he will surpass that number.

The second of our experts’ two Rams vs. 49ers player prop bets involves Christian McCaffrey, San Francisco’s Swiss army knife. McCaffrey has more than 2,000 yards from scrimmage and 21 total touchdowns, and we expect him to build on those numbers on Sunday. He isn't currently listed yet either, but should have a line set at around 80 rushing yards at DraftKings, and our experts expect him to close the season strong and surpass that number on Sunday.

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How to Take our Expert Rams vs. 49ers Picks to DraftKings Sportsbook & Earn $150+

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When you sign up for a DraftKings account using this link, and then make your initial wager of $5 or more, you automatically get $150 in bonus bets, no matter if that wager is successful or not. That first bet can come on our Rams vs. 49ers prediction, our Rams vs. 49ers best bets, or any other contest currently available with DraftKings. And that’s not all. DraftKings also gives you the option to opt-in and get a No Sweat Same Game Parlay every day this season.

Just claim this special welcome bonus today and register for a DraftKings account, find the Rams vs. 49ers game in the NFL section and place that first bet.

Betting Odds, Lines & Spread for Rams vs. 49ers with DraftKings

Here are some of the current Rams vs. 49ers odds available at DraftKings Sportsbook. San Francisco is currently listed as a 4-point favorite at -112 odds. That means the bet would be a winner if the 49ers win by five points or more. If the 49ers cover that spread, a $112 wager would return $100 in profit.

The Rams are currently a 4-point underdog at -108 odds, meaning they must win or lose by three points or less for the bet to be successful. A $108 bet would deliver $100 in winnings if the Rams cover the spread. If the team loses by four points, the bet is a push, and you get your original wager back.

If you want to focus on just the money line, Los Angeles is listed as +164 to win, meaning you would get $164 if you bet $100 on them and they win. The 49ers are listed as -198 to win, so if you wager on their money line, you need to bet $198 to walk away with $100.

The game points total is set at 41, with -110 odds that the final will go either over or under that total. If you take one of those two bets, you need to bet $110 to get $100 back if your bet wins.

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Injury Report for Rams vs. 49ers on 1/7

Wide receiver Jajuan Jennings and safeties Ji’Ayir Brown and Tashaun Gipson are all listed as questionable for the 49ers, while tight end Tyler Higbee and tackle Joe Noteboom have already been downgraded to out for Sunday’s contest for the Rams.

Take advantage of this DraftKings welcome bonus by betting on or against our Rams vs. 49ers prediction today.

49ers Resting Starters for Week 18?

The Rams have already made it public that they are planning on sitting several starters. Other than protecting Purdy, the 49ers have not committed to sitting several starters themselves at this time.

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